Laryngopharyngeal Reflux in Chronic Obstructive Lung Disease -- a Multicenter Study

Sanchez Perez JC, Schumann DM, Baumeler L, et al. Chest Journal. 2017 May;151(5):supplement, page A3.

OBJECTIVES: A laryngopharyngeal monitor has been validated to reliably detect LPR. We hypothesize, that LPR, even if silent, may be a contributing factor for the prognosis of, and clinical outcomes of COPD.

RESULTS: Data from 86 patients and 11 healthy controls were included in a preliminary analysis. Patients with COPD had a significantly higher RYAN (upright) score than healthy controls (median 20.2 vs 2.12; p¼0.005) but RYAN (supine) did not differ between the groups. 58% of the patients had pathologic RYAN score compared to 18% of the controls (p¼0.021). RYAN (upright) score was associated with GOLD stage (beta 0.228, 95% CI 5.041 to 162.85; p¼0.037) but there was no association between RYAN
(upright) score and any of the questionnaires. RYAN (supine) showed an association with the Leicester cough questionnaire (beta -0.303, 95% CI -0.129 to -0.022; p¼0.006). There was no association between RYAN (upright or supine) score and gender, age, body mass index, or pack years. 50% (25/50) of the patients with a pathologic Ryan (upright) score were receiving PPIs, compared to 28% (10/36) of patients with normal RYAN (upright) score (HR 2.60, 95% CI 1.04 to 6.5; p¼0.041).


CONCLUSION: Laryngopharyngeal reflux seems to be more common among patients with COPD and may be associated with GOLD stage.


Topics: Pulmonology, 2017

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