“Activity/Stability of Human Pepsin: Implications for Reflux Attributed Laryngeal Disease”September 20, 2017
“Esophageal Testing: What We Have So Far”September 20, 2017
Zelenik K, Matousek P, Urban O, et al. Laryngoscope. 2010 Nov;120(11):2160-2164.
OBJECTIVES: Weakly acid refluxes seem to play an important role in the pathogenesis of extraesophageal reflux. The aim of this study was to evaluate how proportional representation of patients with extraesophageal reflux in a group of patients with globus pharyngeus changes when we use both pH <4.0 as well as pH <5.0 as a pathological threshold for an extraesophageal reflux episode.
RESULTS: Extraesophageal reflux was proven in 23.9% patients with pure globus pharyngeus when standard analysis using only pH <4.0 was used as pathological threshold. If both pH <4.0 and pH <5.0 were used as the pathological threshold, clear extraesophageal reflux was found in four more (8.7%) patients.
CONCLUSION: This study indicates the possible role of weakly acid extraesophageal reflux episodes in some patients with globus pharyngeus. Other studies on this issue, including the use of biological markers such as signs of inflammation, are warranted.